Symbol
Name
ID

Nr3c1
nuclear receptor subfamily 3, group C, member 1
MGI:95824

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Type II diabetes mellitus
Disease(s) Associated with NR3C1	Diabetes mellitus	Type II diabetes mellitus
coronary artery disease

Mouse Phenotypes

abnormal thymocyte apoptosis

decreased thymocyte apoptosis

endocrine/exocrine gland phenotype

abnormal adrenal gland morphology

abnormal adrenal cortex morphology

abnormal adrenal gland zona fasciculata morphology

decreased adrenal gland zona fasciculata size

increased adrenal gland zona fasciculata size

abnormal adrenal gland zona glomerulosa morphology

abnormal adrenal gland zona reticularis morphology

enlarged adrenocortical cells

enlarged adrenocortical cell nuclei

thin adrenal cortex

abnormal adrenal chromaffin cell morphology

absent adrenergic chromaffin cells

absent adrenal medulla

enlarged adrenal glands

small adrenal glands

thymus hypoplasia

abnormal mammary gland growth during pregnancy

abnormal mammary gland alveolus morphology

Availability

Mouse Genotype

Nr3c1^tm1Dage/Nr3c1^tm1Dage

Nr3c1^tm1Gsc/Nr3c1^tm1Gsc

Nr3c1^tm1Ljm/Nr3c1^tm1Ljm

Nr3c1^tm2.1Gsc/Nr3c1^tm2.1Gsc

Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺

Nr3c1^tm1Dage/Nr3c1⁺

Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda
Tg(Lck-cre)548Jxm/0 (conditional)

Nr3c1^tm2Gsc/Nr3c1^tm2Gsc
Tg(Nes-cre)1Kln/0 (conditional)

Nr3c1^tm2Gsc/Nr3c1^tm2Gsc
Tg(Wap-cre)1Gsc/0 (conditional)

Nr3c1^tm1.1Jda/Nr3c1⁺
Tg(Lck-cre)548Jxm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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